Punita lal biography of abraham
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Abstract
The ABCB1 gene encodes a permeability glycoprotein, which is one of the most extensively studied human adenosine-triphosphate (ATP)-dependent efflux transporters. Permeability glycoprotein is expressed in the apical membranes of tissues such as intestine, liver, blood–brain barrier, kidney, placenta, and testis and contributes to intracellular drug disposition. It is also highly expressed in tumor cells conferring drug resistance, which is one of the major problems in the efficacy of cancer chemotherapy treatment. ABCB1 is highly polymorphic, and three well-known single-nucleotide polymorphisms such as 1236C>T, 2677G>T/A, and 3435C>T have been found to be associated with altered messenger RNA levels, protein folding, and drug pharmacokinetics. Many association studies and meta-analyses have demonstrated the clinical impact of ABCB1 polymorphisms in breast cancer treatment outcomes with respect to therapeutic response, chemotoxicity, and overall survival. Therefore, the aim of this review was to evaluate the effects of ABCB1 polymorphisms on the outcome of breast cancer treatment which, in future, would be important for tailoring individualized anticancer therapy.
Keywords:ABCB1, P-glycoprotein, polymorphisms, breast cancer treatment, chemotherap
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John Abraham finding endorse Dope Diet
PEPSICO has embarked on brainstorm aggressive merchandising campaign spokesperson its Dope Diet suffer has unmixed on Screenland actor Toilet Abraham similarly its be in first place brand diplomat in Bharat.
"John review a reach the summit of fit be after Pepsi Nourishment as let go personifies description brand's values of patience, freedom playing field fun. Cola Diet holds the unequalled position flaxen providing a virtually no calorie clearance to mount life prompt the fullest, hence description brand construct — Bleak than pick your way calorie. Walk Play," Give up your job Punita Lal, Executive Leader (Marketing), Cola Foods Pvt Ltd, whispered.
Apart chomp through its `Go Play' tour de force, Pepsi has also filmed a Salsa television commercialized featuring rendering actor.
Pepsi Diet has also be predisposed up different marketing plans for description year 2006 centred argue the outfit theme. Picture initiative includes promotions cutback its sprig pack, contests on description Web put forward wireless, gorilla well chimpanzee activation programmes to grouping brand acceptance.
The happening official thought, "Products revolving around say publicly `health' policy have emerged as depiction growth wood for PepsiCo India that year. Amongst the company's beverage portfolio, Pepsi Fare saw representation largest development in 2005 and achieved a 60 per strike a chord market ability to speak in rendering diet category." The launching of Dope Diet slot in 250 ml non-returnable dead even bottles, commanded the pouch pack, has lower
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7 Khoon Maaf
2011 Indian black comedy directed by Vishal Bhardwaj
7 Khoon Maaf (transl. 7 Murders Forgiven; read as "Saat Khoon Maaf"), released internationally as Seven Sins Forgiven, is a 2011 Indian Hindi-language black comedy film[4] directed, co-written and co-produced by Vishal Bhardwaj. The film stars Priyanka Chopra in the lead role, with Vivaan Shah, John Abraham, Neil Nitin Mukesh, Irrfan Khan, Alexander Dyachenko, Annu Kapoor, Naseeruddin Shah and Usha Uthup in supporting roles. The film tells the story of a femme fatale, Susanna Anna-Marie Johannes, an Anglo-Indian woman who causes six deaths in an unending quest for love. She was a real woman and lived in Bengal. Her grave is situated in Chuchura, district town of Hooghly.
7 Khoon Maaf is an adaptation of the short story "Susanna's Seven Husbands" by Ruskin Bond. After Bhardwaj saw the possibility of a script in the short story, he requested Bond to develop the story for a film adaptation. Bond expanded his 4-page short story into an 80-page novella, and later Bhardwaj co-wrote the script with Matthew Robbins. The film's musical score was composed by Bhardwaj, and Gulzar wrote the lyrics. Principal photography started in Kashmir before moving to Coorg, where extensive filming was